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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C16278
http://purl.obolibrary.org/obo/NCIT_C16278
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|---|---|
| Preferred Name | Alpha-Fetoprotein |
| Definitions |
Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation. |
|---|---|
| prefLabel | Alpha-Fetoprotein
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| label | Alpha-Fetoprotein
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| code | C16278
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| prefixIRI | NCIT:C16278
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| OMIM_Number | 104150
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| in_subset | |
| Display_Name | Alpha-Fetoprotein
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| Preferred_Name | Alpha-Fetoprotein
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| Contributing_Source | CTRP
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| Swiss_Prot | P02771
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| Legacy Concept Name | Alpha-Fetoprotein
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| DesignNote | Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink)
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| type | |
| ALT_DEFINITION | A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor.
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| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C1307640
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