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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C162568
http://purl.obolibrary.org/obo/NCIT_C162568
|
|---|---|
| Preferred Name | Infigratinib Mesylate |
| Definitions |
The mesylate salt of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Upon administration, infigratinib selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The mesylate salt of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Upon administration, infigratinib selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival. |
|---|---|
| label | Infigratinib Mesylate
|
| prefLabel | Infigratinib Mesylate
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| in_subset | |
| Preferred_Name | Infigratinib Mesylate
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| Is_Value_For_GDC_Property | |
| Maps_To | Infigratinib Mesylate
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| FDA_UNII_Code | E223Z0KWCC
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| prefixIRI | NCIT:C162568
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| Contributing_Source | FDA
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| subClassOf | |
| code | C162568
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| type | |
| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 1310746-12-3
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| NCI_META_CUI | CL971083
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