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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C162533
http://purl.obolibrary.org/obo/NCIT_C162533
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|---|---|
| Preferred Name | Src Kinase Inhibitor AP 23846 |
| Definitions |
A novel small molecule Src family kinase inhibitor with potential antiangiogenic activity. Upon administration, Src kinase inhibitor AP23846 selectively binds to and stabilizes an inactive ATP-binding site conformation leading to reduced Src kinase activity. This may reduce the production of pro-angiogenic factors, vascular endothelial growth factor (VEGF) and interleukin (IL)-8. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation, survival, migration, invasion and angiogenesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A novel small molecule Src family kinase inhibitor with potential antiangiogenic activity. Upon administration, Src kinase inhibitor AP23846 selectively binds to and stabilizes an inactive ATP-binding site conformation leading to reduced Src kinase activity. This may reduce the production of pro-angiogenic factors, vascular endothelial growth factor (VEGF) and interleukin (IL)-8. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation, survival, migration, invasion and angiogenesis. |
|---|---|
| prefLabel | Src Kinase Inhibitor AP 23846
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| label | Src Kinase Inhibitor AP 23846
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| NCI_META_CUI | CL971115
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| code | C162533
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| prefixIRI | NCIT:C162533
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| in_subset | |
| Preferred_Name | Src Kinase Inhibitor AP 23846
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| Maps_To | Src Kinase Inhibitor AP 23846
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| CAS_Registry | 878654-51-4
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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