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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C162480
http://purl.obolibrary.org/obo/NCIT_C162480
|
|---|---|
| Preferred Name | MetAP2 Inhibitor APL-1202 |
| Definitions |
An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival. |
|---|---|
| prefLabel | MetAP2 Inhibitor APL-1202
|
| label | MetAP2 Inhibitor APL-1202
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| NCI_META_CUI | CL970968
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| PDQ_Closed_Trial_Search_ID | 798664
|
| code | C162480
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| Has_Target | |
| prefixIRI | NCIT:C162480
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| in_subset | |
| Preferred_Name | MetAP2 Inhibitor APL-1202
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| Maps_To | MetAP2 Inhibitor APL-1202
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| NCI_Drug_Dictionary_ID | 798664
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 798664
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| Semantic_Type | Pharmacologic Substance
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