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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C162348
http://purl.obolibrary.org/obo/NCIT_C162348
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|---|---|
| Preferred Name | Exatecan Mesylate Anhydrous |
| Definitions |
The anhydrous, mesylate salt form of exatecan, a semisynthetic, water-soluble derivative of camptothecin, with antineoplastic activity. Upon administration, exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting re-ligation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The anhydrous, mesylate salt form of exatecan, a semisynthetic, water-soluble derivative of camptothecin, with antineoplastic activity. Upon administration, exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting re-ligation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. |
|---|---|
| prefLabel | Exatecan Mesylate Anhydrous
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| label | Exatecan Mesylate Anhydrous
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| NCI_META_CUI | CL970851
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| code | C162348
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| prefixIRI | NCIT:C162348
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| in_subset | |
| Preferred_Name | Exatecan Mesylate Anhydrous
|
| FDA_UNII_Code | Y76278R9RJ
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| Contributing_Source | FDA
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| Maps_To | Exatecan Mesylate Anhydrous
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| CAS_Registry | 169869-90-3
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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