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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C162345
http://purl.obolibrary.org/obo/NCIT_C162345
|
|---|---|
| Preferred Name | TRPM8 Agonist D-3263 |
| Definitions |
A small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8), with potential antineoplastic activity. Upon administration, TRPM8 agonist D-3263 targets, binds to and activates TRPM8, which may result in an increase in intracellular calcium and sodium influx; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and benign prostatic hyperplasia (BPH). TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in BPH and in prostate cancer.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8), with potential antineoplastic activity. Upon administration, TRPM8 agonist D-3263 targets, binds to and activates TRPM8, which may result in an increase in intracellular calcium and sodium influx; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and benign prostatic hyperplasia (BPH). TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in BPH and in prostate cancer. |
|---|---|
| prefLabel | TRPM8 Agonist D-3263
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| label | TRPM8 Agonist D-3263
|
| NCI_META_CUI | CL970854
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| code | C162345
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| prefixIRI | NCIT:C162345
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| in_subset | |
| Preferred_Name | TRPM8 Agonist D-3263
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| FDA_UNII_Code | 70FBL3TX3E
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| Contributing_Source | FDA
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| Maps_To | TRPM8 Agonist D-3263
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| CAS_Registry | 947257-66-1
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| Legacy Concept Name | Enteric-Coated_TRPM8_Agonist_D-3263_Hydrochloride
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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