Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1623
http://purl.obolibrary.org/obo/NCIT_C1623
Preferred Name

Patupilone
Definitions
A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.
prefLabel
Patupilone
label
Patupilone
PDQ_Closed_Trial_Search_ID
38702
code
C1623
Has_Target
prefixIRI
NCIT:C1623
in_subset
Display_Name
Patupilone
Preferred_Name
Patupilone
FDA_UNII_Code
UEC0H0URSE
Contributing_Source
CTRP
FDA
Chemical_Formula
C27H41NO6S
Maps_To
Patupilone
CAS_Registry
152044-54-7
NCI_Drug_Dictionary_ID
38702
Legacy Concept Name
Epothilone_B
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. It is a type of epothilone.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38702
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0297960
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