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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1620
http://purl.obolibrary.org/obo/NCIT_C1620
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|---|---|
| Preferred Name | Becatecarin |
| Definitions |
A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04) |
|---|---|
| prefLabel | Becatecarin
|
| label | Becatecarin
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| PDQ_Closed_Trial_Search_ID | 42257
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| code | C1620
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| Has_Target | |
| prefixIRI | NCIT:C1620
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| in_subset |
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| Display_Name | Becatecarin
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| Preferred_Name | Becatecarin
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| FDA_UNII_Code | A60X6MBU6G
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C33H34Cl2N4O7
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| Maps_To | Becatecarin
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| CAS_Registry | 119673-08-4
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| NSC Number | 655649
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| NCI_Drug_Dictionary_ID | 42257
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| Legacy Concept Name | Rebeccamycin_Analogue
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called antitumor antibiotics and topoisomerase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42257
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0936065
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