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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1619
http://purl.obolibrary.org/obo/NCIT_C1619
|
|---|---|
| Preferred Name | LMB-7 Immunotoxin |
| Definitions |
A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04) |
|---|---|
| prefLabel | LMB-7 Immunotoxin
|
| label | LMB-7 Immunotoxin
|
| PDQ_Closed_Trial_Search_ID | 42683
|
| code | C1619
|
| prefixIRI | NCIT:C1619
|
| in_subset | |
| Preferred_Name | LMB-7 Immunotoxin
|
| Maps_To | LMB-7 Immunotoxin
|
| NSC Number |
658931
659639
|
| NCI_Drug_Dictionary_ID | 42683
|
| Legacy Concept Name | LMB-7_Immunotoxin
|
| type | |
| ALT_DEFINITION | A toxic substance linked to an antibody that attaches to tumor cells and kills them.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42683
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| UMLS_CUI | C0296314
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