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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C161864
http://purl.obolibrary.org/obo/NCIT_C161864
|
|---|---|
| Preferred Name | Revdofilimab |
| Definitions |
An agonistic humanized IgG1 monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, revdofilimab selectively binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An agonistic humanized IgG1 monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, revdofilimab selectively binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation. |
|---|---|
| prefLabel | Revdofilimab
|
| label | Revdofilimab
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| NCI_META_CUI | CL970355
|
| PDQ_Closed_Trial_Search_ID | 792559
|
| code | C161864
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| Has_Target | |
| prefixIRI | NCIT:C161864
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| in_subset |
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| Display_Name | Revdofilimab
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| Preferred_Name | Revdofilimab
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| FDA_UNII_Code | 2Y83Y2ORD3
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Revdofilimab
Anti-OX40 Agonist Monoclonal Antibody ABBV-368
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| CAS_Registry | 2230138-89-1
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| NCI_Drug_Dictionary_ID | 792559
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792559
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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