Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1617
http://purl.obolibrary.org/obo/NCIT_C1617
|
|---|---|
| Preferred Name | BR96-Doxorubicin Immunoconjugate |
| Definitions |
An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types. Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types. Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI) |
|---|---|
| prefLabel | BR96-Doxorubicin Immunoconjugate
|
| label | BR96-Doxorubicin Immunoconjugate
|
| PDQ_Closed_Trial_Search_ID | 38477
|
| code | C1617
|
| prefixIRI | NCIT:C1617
|
| in_subset | |
| Preferred_Name | BR96-Doxorubicin Immunoconjugate
|
| Maps_To | BR96-Doxorubicin Immunoconjugate
|
| NCI_Drug_Dictionary_ID | 38477
|
| Legacy Concept Name | BR96-Doxorubicin_Immunoconjugate
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38477
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| UMLS_CUI | C0295525
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |