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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1614
http://purl.obolibrary.org/obo/NCIT_C1614
|
|---|---|
| Preferred Name | KRN5500 |
| Definitions |
A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. (NCI04) |
|---|---|
| prefLabel | KRN5500
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| label | KRN5500
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| PDQ_Closed_Trial_Search_ID | 42581
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| code | C1614
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| prefixIRI | NCIT:C1614
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| in_subset |
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| Display_Name | KRN5500
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| Preferred_Name | KRN5500
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| FDA_UNII_Code | 8VH13L5K20
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| Contributing_Source |
CTRP
FDA
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| Maps_To | KRN5500
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| CAS_Registry | 151276-95-8
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| NSC Number | 650426
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| NCI_Drug_Dictionary_ID | 42581
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| Legacy Concept Name | KRN5500
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to a family of drugs called antitumor antibiotics. It is an anthracycline.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42581
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0294829
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