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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1612
http://purl.obolibrary.org/obo/NCIT_C1612
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|---|---|
| Preferred Name | Glufosfamide |
| Definitions |
A compound consisting of the mustard agent ifosforamide conjugated to glucose, with potential alkylating activity. Glufosfamide is cleaved by glucosidases in tumor cells and forms ifosforamide. In turn, ifosforamide alkylates and forms DNA crosslinks, thereby inhibiting DNA replication and subsequent cell growth. The glucose moiety may enhance this agent's uptake by tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A compound consisting of the mustard agent ifosforamide conjugated to glucose, with potential alkylating activity. Glufosfamide is cleaved by glucosidases in tumor cells and forms ifosforamide. In turn, ifosforamide alkylates and forms DNA crosslinks, thereby inhibiting DNA replication and subsequent cell growth. The glucose moiety may enhance this agent's uptake by tumor cells. |
|---|---|
| prefLabel | Glufosfamide
|
| label | Glufosfamide
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| PDQ_Closed_Trial_Search_ID | 42676
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| code | C1612
|
| prefixIRI | NCIT:C1612
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| in_subset |
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| Display_Name | Glufosfamide
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| Preferred_Name | Glufosfamide
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| FDA_UNII_Code | 1W5N8SZD9A
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C10H21Cl2N2O7P
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| Maps_To | Glufosfamide
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| CAS_Registry | 132682-98-5
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| NCI_Drug_Dictionary_ID | 42676
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| Legacy Concept Name | Glufosfamide
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42676
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0380377
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