Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1603
http://purl.obolibrary.org/obo/NCIT_C1603
Preferred Name

Tallimustine
Definitions
A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich regions in the minor groove of DNA and alkylates at the N3 position of adenine in a highly sequence-specific manner. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. Moreover, unlike other clinical nitrogen mustards, tallimustine does not carry out guanine-N7 alkylation in the major groove of DNA, which may lead to a high selectivity of action.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich regions in the minor groove of DNA and alkylates at the N3 position of adenine in a highly sequence-specific manner. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. Moreover, unlike other clinical nitrogen mustards, tallimustine does not carry out guanine-N7 alkylation in the major groove of DNA, which may lead to a high selectivity of action.
prefLabel
Tallimustine
label
Tallimustine
PDQ_Closed_Trial_Search_ID
42145
code
C1603
prefixIRI
NCIT:C1603
in_subset
Preferred_Name
Tallimustine
FDA_UNII_Code
71193OXG6S
Contributing_Source
FDA
Chemical_Formula
C32H38Cl2N10O4
Maps_To
Tallimustine
CAS_Registry
115308-98-0
NCI_Drug_Dictionary_ID
42145
Legacy Concept Name
Tallimustine
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42145
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0286890
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