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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C160203
http://purl.obolibrary.org/obo/NCIT_C160203
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|---|---|
| Preferred Name | PIM Kinase Inhibitor TP-3654 |
| Definitions |
An orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival. |
|---|---|
| prefLabel | PIM Kinase Inhibitor TP-3654
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| label | PIM Kinase Inhibitor TP-3654
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| NCI_META_CUI | CL969336
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| PDQ_Closed_Trial_Search_ID | 797841
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| code | C160203
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| Has_Target | |
| prefixIRI | NCIT:C160203
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| in_subset |
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| Display_Name | PIM Kinase Inhibitor TP-3654
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| Preferred_Name | PIM Kinase Inhibitor TP-3654
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| FDA_UNII_Code | EOB0N7BOY4
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| Contributing_Source |
CTRP
FDA
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| Maps_To | PIM Kinase Inhibitor TP-3654
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| CAS_Registry | 1361951-15-6
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| NCI_Drug_Dictionary_ID | 797841
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| Legacy Concept Name | Pim_Kinase_Inhibitor_SGI-1776
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 797841
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| Semantic_Type | Pharmacologic Substance
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