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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Cidofovir | |
| Synonyms |
|
|
| Definitions |
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1600 |
|
| ALT_DEFINITION |
A drug used to treat infection caused by viruses.
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|
| CAS_Registry |
149394-66-1
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|
| CHEBI_ID |
CHEBI:59495
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|
| Chemical_Formula |
C8H14N3O6P.2H2O
|
|
| code |
C1600
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.
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|
| Display_Name |
Cidofovir
|
|
| FDA_UNII_Code |
JIL713Q00N
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|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Cidofovir
|
|
| Legacy Concept Name |
Cidofovir
|
|
| NCI_Drug_Dictionary_ID |
42545
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|
| PDQ_Closed_Trial_Search_ID |
42545
|
|
| PDQ_Open_Trial_Search_ID |
42545
|
|
| Preferred_Name |
Cidofovir
|
|
| prefixIRI |
NCIT:C1600
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|
| prefLabel |
Cidofovir
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|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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|
| UMLS_CUI |
C0286079
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|
| subClassOf |
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