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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1598
http://purl.obolibrary.org/obo/NCIT_C1598
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|---|---|
| Preferred Name | Gusperimus Trihydrochloride |
| Definitions |
A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04) |
|---|---|
| prefLabel | Gusperimus Trihydrochloride
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| label | Gusperimus Trihydrochloride
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| PDQ_Closed_Trial_Search_ID | 40369
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| code | C1598
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| prefixIRI | NCIT:C1598
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| in_subset | |
| Preferred_Name | Gusperimus Trihydrochloride
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| FDA_UNII_Code | QZS4144IO0
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| Contributing_Source | FDA
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| Chemical_Formula | C17H37N7O3.3HCl
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| Maps_To | Gusperimus Trihydrochloride
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| CAS_Registry | 84937-45-1
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| NSC Number | 356894
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| NCI_Drug_Dictionary_ID | 40369
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| Legacy Concept Name | Gusperimus
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40369
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0284559
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