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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C159537
http://purl.obolibrary.org/obo/NCIT_C159537
|
|---|---|
| Preferred Name | Radium Ra 224-labeled Calcium Carbonate Microparticles |
| Definitions |
A radiopharmaceutical composed of biodegradable calcium carbonate microspheres labeled with the alpha-emitting radioisotope radium Ra 224, with antineoplastic activity. Upon intraperitoneal (IP) administration of the radium Ra 224-labeled calcium carbonate microparticles, Ra 224 kills tumor cells through local emission of high energy alpha particles, causing DNA double-strand breaks. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy tissue.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radiopharmaceutical composed of biodegradable calcium carbonate microspheres labeled with the alpha-emitting radioisotope radium Ra 224, with antineoplastic activity. Upon intraperitoneal (IP) administration of the radium Ra 224-labeled calcium carbonate microparticles, Ra 224 kills tumor cells through local emission of high energy alpha particles, causing DNA double-strand breaks. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy tissue. |
|---|---|
| prefLabel | Radium Ra 224-labeled Calcium Carbonate Microparticles
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| label | Radium Ra 224-labeled Calcium Carbonate Microparticles
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| NCI_META_CUI | CL951431
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| PDQ_Closed_Trial_Search_ID | 797476
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| code | C159537
|
| prefixIRI | NCIT:C159537
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| in_subset | |
| Preferred_Name | Radium Ra 224-labeled Calcium Carbonate Microparticles
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| Maps_To | Radium Ra 224-labeled Calcium Carbonate Microparticles
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| NCI_Drug_Dictionary_ID | 797476
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 797476
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| Semantic_Type | Pharmacologic Substance
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