Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C159410
http://purl.obolibrary.org/obo/NCIT_C159410
|
|---|---|
| Preferred Name | EBNA-1 inhibitor VK-2019 |
| Definitions |
An orally available, small molecule inhibitor of Epstein-Barr nuclear antigen 1 (EBNA-1) with potential antineoplastic activity. Upon administration, EBNA-1 inhibitor VK-2019 binds to EBNA-1 and inhibits EBNA-1 DNA binding activity. This disrupts the replication, maintenance and segregation of the Epstein-Barr virus (EBV) genome, which may lead to tumor cell death in EBV-associated malignancies. EBNA1, a sequence-specific DNA binding protein, plays an important role in EBV episomal genome maintenance and gene transactivation.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available, small molecule inhibitor of Epstein-Barr nuclear antigen 1 (EBNA-1) with potential antineoplastic activity. Upon administration, EBNA-1 inhibitor VK-2019 binds to EBNA-1 and inhibits EBNA-1 DNA binding activity. This disrupts the replication, maintenance and segregation of the Epstein-Barr virus (EBV) genome, which may lead to tumor cell death in EBV-associated malignancies. EBNA1, a sequence-specific DNA binding protein, plays an important role in EBV episomal genome maintenance and gene transactivation. |
|---|---|
| prefLabel | EBNA-1 inhibitor VK-2019
|
| label | EBNA-1 inhibitor VK-2019
|
| NCI_META_CUI | CL951268
|
| PDQ_Closed_Trial_Search_ID | 797645
|
| code | C159410
|
| Has_Target | |
| prefixIRI | NCIT:C159410
|
| in_subset |
See more
See less
|
| Display_Name | EBNA-1 inhibitor VK-2019
|
| Preferred_Name | EBNA-1 inhibitor VK-2019
|
| Contributing_Source | CTRP
|
| Maps_To | EBNA-1 inhibitor VK-2019
|
| NCI_Drug_Dictionary_ID | 797645
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 797645
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |