Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1594
http://purl.obolibrary.org/obo/NCIT_C1594
Preferred Name

Anthracycline Antineoplastic Antibiotic
Definitions
An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
prefLabel
Anthracycline Antineoplastic Antibiotic
label
Anthracycline Antineoplastic Antibiotic
CHEBI_ID
CHEBI:49322
code
C1594
Has_Target
prefixIRI
NCIT:C1594
in_subset
Display_Name
Anthracycline Antineoplastic Antibiotic
Preferred_Name
Anthracycline Antineoplastic Antibiotic
Contributing_Source
CTRP
Legacy Concept Name
Anthracycline_Antibiotic
type
ALT_DEFINITION
A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.
subClassOf
Semantic_Type
Chemical Viewed Functionally
UMLS_CUI
C0282564
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