loading...| Preferred Name |
Antineoplastic Alkylating Agent |
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| Synonyms |
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| Definitions |
An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1590 |
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| code |
C1590 |
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| definition |
An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth. |
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| label |
Antineoplastic Alkylating Agent |
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| Legacy Concept Name |
Antineoplastic_Alkylating_Agent |
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| Preferred_Name |
Antineoplastic Alkylating Agent |
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| prefixIRI |
NCIT:C1590 |
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| prefLabel |
Antineoplastic Alkylating Agent |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C0282532 |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1590 | NCIT | LOOM |