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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1587
http://purl.obolibrary.org/obo/NCIT_C1587
|
|---|---|
| Preferred Name | Idarubicin Hydrochloride |
| Definitions |
The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds |
|---|---|
| prefLabel | Idarubicin Hydrochloride
|
| label | Idarubicin Hydrochloride
|
| PDQ_Closed_Trial_Search_ID | 39753
|
| code | C1587
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| Has_Target | |
| prefixIRI | NCIT:C1587
|
| in_subset |
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| Display_Name | Idarubicin Hydrochloride
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| Preferred_Name | Idarubicin Hydrochloride
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| FDA_UNII_Code | 5VV3MDU5IE
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C26H27NO9.HCl
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| Maps_To | Idarubicin Hydrochloride
|
| CAS_Registry | 57852-57-0
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| NSC Number | 256439
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| NCI_Drug_Dictionary_ID | 39753
|
| Legacy Concept Name | Idarubicin_Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39753
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| Accepted_Therapeutic_Use_For | In combination therapies for acute myelogenous leukemia and pediatric acute lymphocytic leukemia.
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0939353
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| Delete | Subject | Author | Type | Created |
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