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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C158604
http://purl.obolibrary.org/obo/NCIT_C158604
|
|---|---|
| Preferred Name | Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901 |
| Definitions |
A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes CLIC-1901 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes CLIC-1901 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies. |
|---|---|
| prefLabel | Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901
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| label | Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901
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| NCI_META_CUI | CL938077
|
| PDQ_Closed_Trial_Search_ID | 797095
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| code | C158604
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| prefixIRI | NCIT:C158604
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| in_subset | |
| Preferred_Name | Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901
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| Maps_To | Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901
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| NCI_Drug_Dictionary_ID | 797095
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 797095
|
| Semantic_Type |
Pharmacologic Substance
Cell
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