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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C158510
http://purl.obolibrary.org/obo/NCIT_C158510
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|---|---|
| Preferred Name | BCL2 Inhibitor VOB560 |
| Definitions |
An inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon intravenous administration, Bcl-2 inhibitor VOB560 binds to and inhibits the activity of Bcl-2, thereby restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in many cancer types and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon intravenous administration, Bcl-2 inhibitor VOB560 binds to and inhibits the activity of Bcl-2, thereby restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in many cancer types and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. |
|---|---|
| prefLabel | BCL2 Inhibitor VOB560
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| label | BCL2 Inhibitor VOB560
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| NCI_META_CUI | CL938051
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| PDQ_Closed_Trial_Search_ID | 797175
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| code | C158510
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| prefixIRI | NCIT:C158510
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| in_subset |
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| Display_Name | BCL2 Inhibitor VOB560
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| Preferred_Name | BCL2 Inhibitor VOB560
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| Contributing_Source | CTRP
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| Maps_To | Bcl-2 Inhibitor S65487
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| NCI_Drug_Dictionary_ID | 797175
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 797175
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| Semantic_Type | Pharmacologic Substance
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