Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1583
http://purl.obolibrary.org/obo/NCIT_C1583
Preferred Name

Daunorubicin Hydrochloride
Definitions
The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
prefLabel
Daunorubicin Hydrochloride
label
Daunorubicin Hydrochloride
PDQ_Closed_Trial_Search_ID
39779
code
C1583
Has_Target
prefixIRI
NCIT:C1583
in_subset
Display_Name
Daunorubicin Hydrochloride
Preferred_Name
Daunorubicin Hydrochloride
FDA_UNII_Code
UD984I04LZ
Contributing_Source
CTRP
FDA
Chemical_Formula
C27H29NO10.HCl
Maps_To
Daunorubicin Hydrochloride
CAS_Registry
23541-50-6
NSC Number
82151
83142
NCI_Drug_Dictionary_ID
39779
Legacy Concept Name
Daunomycin
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
A drug used to treat acute leukemias and some other types of cancer. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Cerubidine is a type of anthracycline antibiotic and a type of topoisomerase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
39779
Accepted_Therapeutic_Use_For
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C0282123
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display