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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1576
http://purl.obolibrary.org/obo/NCIT_C1576
|
|---|---|
| Preferred Name | Sedoxantrone Trihydrochloride |
| Definitions |
The trihydrochloride salt of the anthrapyrazole antineoplastic antibiotic sedoxantrone with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The trihydrochloride salt of the anthrapyrazole antineoplastic antibiotic sedoxantrone with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. |
|---|---|
| prefLabel | Sedoxantrone Trihydrochloride
|
| label | Sedoxantrone Trihydrochloride
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| PDQ_Closed_Trial_Search_ID | 42217
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| code | C1576
|
| prefixIRI | NCIT:C1576
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| in_subset | |
| Preferred_Name | Sedoxantrone Trihydrochloride
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| FDA_UNII_Code | X9GSL37ED0
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| Contributing_Source | FDA
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| Chemical_Formula | C21H27N5OS.3ClH
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| Maps_To | Sedoxantrone Trihydrochloride
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| CAS_Registry | 119221-49-7
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| NSC Number | 635371
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| NCI_Drug_Dictionary_ID | 42217
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| Legacy Concept Name | Sedoxantrone_Trihydrochloride
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of some types of cancer. Sedoxantrone trihydrochloride binds to DNA and stops cells, including cancer cells, from repairing damage to DNA and from making more DNA, RNA, and protein. It is a type of DNA intercalator.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42217
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0281727
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