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Biological and Environmental Research Ontology
| Preferred Name | Mepolizumab | |
| Synonyms |
|
|
| Definitions |
A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. Upon subcutaneous administration, mepolizumab selectively binds to IL-5, preventing it from associating with interleukin-5 receptor subunit alpha (IL5RA) on the surface of eosinophils and their progenitors. IL-5 plays a role in the regulation of eosinophil development from hematopoietic progenitors as well as eosinophil maturation, differentiation, mobilization, activation, and survival. IL-5 also play a role in the pathogenesis of some phenotypes of hypereosinophilic syndrome (HES). |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C157376 |
|
| CAS_Registry |
196078-29-2
|
|
| code |
C157376
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|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. Upon subcutaneous administration, mepolizumab selectively binds to IL-5, preventing it from associating with interleukin-5 receptor subunit alpha (IL5RA) on the surface of eosinophils and their progenitors. IL-5 plays a role in the regulation of eosinophil development from hematopoietic progenitors as well as eosinophil maturation, differentiation, mobilization, activation, and survival. IL-5 also play a role in the pathogenesis of some phenotypes of hypereosinophilic syndrome (HES).
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|
| Display_Name |
Mepolizumab
|
|
| FDA_UNII_Code |
90Z2UF0E52
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|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Mepolizumab
|
|
| NCI_Drug_Dictionary_ID |
796922
|
|
| NCI_META_CUI |
CL936998
|
|
| PDQ_Closed_Trial_Search_ID |
796922
|
|
| PDQ_Open_Trial_Search_ID |
796922
|
|
| Preferred_Name |
Mepolizumab
|
|
| prefixIRI |
NCIT:C157376
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|
| prefLabel |
Mepolizumab
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| subClassOf |
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