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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1571
http://purl.obolibrary.org/obo/NCIT_C1571
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|---|---|
| Preferred Name | Alvocidib Hydrochloride |
| Definitions |
A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. |
|---|---|
| label | Alvocidib Hydrochloride
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| prefLabel | Alvocidib Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| Legacy Concept Name | Flavopiridol
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| in_subset |
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| Preferred_Name | Alvocidib Hydrochloride
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C21H20ClNO5.HCl
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| Display_Name | Alvocidib Hydrochloride
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| Maps_To | Alvocidib Hydrochloride
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| PDQ_Open_Trial_Search_ID | 42068
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| Has_Target | |
| UMLS_CUI | C0281603
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| FDA_UNII_Code | D48MS3A6N9
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| prefixIRI | NCIT:C1571
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| NCI_Drug_Dictionary_ID | 42068
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C1571
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of several types of cancer. It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent kinase (CDK) inhibitor.
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| NSC Number | 649890
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| PDQ_Closed_Trial_Search_ID | 42068
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 131740-09-5
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