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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1568
http://purl.obolibrary.org/obo/NCIT_C1568
|
|---|---|
| Preferred Name | Safingol |
| Definitions |
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. |
|---|---|
| prefLabel | Safingol
|
| label | Safingol
|
| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 41910
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| code | C1568
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| Has_Target | |
| prefixIRI | NCIT:C1568
|
| in_subset |
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| Display_Name | Safingol
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| Preferred_Name | Safingol
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| FDA_UNII_Code | OWA98U788S
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C18H39NO2
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| Maps_To | Safingol
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| CAS_Registry | 15639-50-6
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| NSC Number | 714503
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| NCI_Drug_Dictionary_ID | 41910
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| Legacy Concept Name | Dihydrosphingosine
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41910
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0281466
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