Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C156740
http://purl.obolibrary.org/obo/NCIT_C156740
|
|---|---|
| Preferred Name | Murizatoclax |
| Definitions |
An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor AMG 397 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor AMG 397 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival. |
|---|---|
| label | Murizatoclax
|
| prefLabel | Murizatoclax
|
| in_subset |
See more
See less
|
| Preferred_Name | Murizatoclax
|
| Is_Value_For_GDC_Property | |
| Display_Name | Murizatoclax
|
| Maps_To |
Murizatoclax
MCL-1 inhibitor AMG 397
|
| PDQ_Open_Trial_Search_ID | 795697
|
| FDA_UNII_Code | BO0V7196L2
|
| prefixIRI | NCIT:C156740
|
| NCI_Drug_Dictionary_ID | 795697
|
| Contributing_Source |
CTRP
FDA
|
| subClassOf | |
| code | C156740
|
| type | |
| PDQ_Closed_Trial_Search_ID | 795697
|
| Semantic_Type | Pharmacologic Substance
|
| CAS_Registry | 2245848-05-7
|
| NCI_META_CUI | CL935903
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |