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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C156734
http://purl.obolibrary.org/obo/NCIT_C156734
|
|---|---|
| Preferred Name | Nurulimab |
| Definitions |
A monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, nurulimab targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, nurulimab targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system. |
|---|---|
| prefLabel | Nurulimab
|
| label | Nurulimab
|
| NCI_META_CUI | CL935901
|
| PDQ_Closed_Trial_Search_ID | 795594
|
| code | C156734
|
| prefixIRI | NCIT:C156734
|
| in_subset | |
| Preferred_Name | Nurulimab
|
| FDA_UNII_Code | 894KSI08XK
|
| Contributing_Source | FDA
|
| Maps_To |
Anti-CTLA-4 Monoclonal Antibody BCD-145
Nurulimab
|
| CAS_Registry | 2168561-20-2
|
| NCI_Drug_Dictionary_ID | 795594
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 795594
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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