Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C156697
http://purl.obolibrary.org/obo/NCIT_C156697
|
|---|---|
| Preferred Name | Halichondrin Analogue E7130 |
| Definitions |
A halichondrin analogue derived from a marine sponge with potential antineoplastic activity. Upon intravenous infusion, halichondrin analogue E7130 may bind to the vinca domain of tubulin and inhibit the polymerization of tubulin and the assembly of microtubules, thereby inhibiting mitotic spindle assembly and inducing cell cycle arrest at the G2/M phase.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A halichondrin analogue derived from a marine sponge with potential antineoplastic activity. Upon intravenous infusion, halichondrin analogue E7130 may bind to the vinca domain of tubulin and inhibit the polymerization of tubulin and the assembly of microtubules, thereby inhibiting mitotic spindle assembly and inducing cell cycle arrest at the G2/M phase. |
|---|---|
| prefLabel | Halichondrin Analogue E7130
|
| label | Halichondrin Analogue E7130
|
| NCI_META_CUI | CL935716
|
| PDQ_Closed_Trial_Search_ID | 795713
|
| code | C156697
|
| Has_Target | |
| prefixIRI | NCIT:C156697
|
| in_subset | |
| Preferred_Name | Halichondrin Analogue E7130
|
| FDA_UNII_Code | R6WE4X56YH
|
| Contributing_Source | FDA
|
| Maps_To | Halichondrin Analogue E7130
|
| NCI_Drug_Dictionary_ID | 795713
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 795713
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |