Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C156402
http://purl.obolibrary.org/obo/NCIT_C156402
|
|---|---|
| Preferred Name | Anti-NRP1 Antibody ASP1948 |
| Definitions |
A human immunoglobulin G4 (IgG4) monoclonal antibody directed against neuropilin-1 (NRP1; CD304; BDCA-4), with potential immunomodulatory and antineoplastic activities. Upon administration, anti-NRP1 antibody ASP1948 specifically targets and binds to NRP1. This prevents the binding of NRP1 to its ligand and may block the immune inhibitory actions of regulatory T-cells (Tregs) mediated by the interaction of NRP1 with its ligand. This may enhance the immune response against tumor cells. NRP1 is a transmembrane co-receptor protein expressed in Tregs; it plays an important role in maintaining the stability and function of Tregs.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A human immunoglobulin G4 (IgG4) monoclonal antibody directed against neuropilin-1 (NRP1; CD304; BDCA-4), with potential immunomodulatory and antineoplastic activities. Upon administration, anti-NRP1 antibody ASP1948 specifically targets and binds to NRP1. This prevents the binding of NRP1 to its ligand and may block the immune inhibitory actions of regulatory T-cells (Tregs) mediated by the interaction of NRP1 with its ligand. This may enhance the immune response against tumor cells. NRP1 is a transmembrane co-receptor protein expressed in Tregs; it plays an important role in maintaining the stability and function of Tregs. |
|---|---|
| prefLabel | Anti-NRP1 Antibody ASP1948
|
| label | Anti-NRP1 Antibody ASP1948
|
| NCI_META_CUI | CL563090
|
| PDQ_Closed_Trial_Search_ID | 795699
|
| code | C156402
|
| Has_Target | |
| prefixIRI | NCIT:C156402
|
| in_subset |
See more
See less
|
| Display_Name | Anti-NRP1 Antibody ASP1948
|
| Preferred_Name | Anti-NRP1 Antibody ASP1948
|
| FDA_UNII_Code | 857Y17E6U4
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To |
Anti-NRP1 Antibody ASP1948
Monoclonal Antibody ASP1948
|
| NCI_Drug_Dictionary_ID | 795699
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 795699
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |