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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1564
http://purl.obolibrary.org/obo/NCIT_C1564
|
|---|---|
| Preferred Name | Pyrazoloacridine |
| Definitions |
A 9-methoxy acridine compound containing a reducible 5-nitro substituent. Pyrazoloacridine appears to intercalate into DNA and inhibit RNA synthesis, DNA synthesis, and the activities of topoisomerases I and II, thereby causing cytotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 9-methoxy acridine compound containing a reducible 5-nitro substituent. Pyrazoloacridine appears to intercalate into DNA and inhibit RNA synthesis, DNA synthesis, and the activities of topoisomerases I and II, thereby causing cytotoxicity. (NCI04) |
|---|---|
| label | Pyrazoloacridine
|
| prefLabel | Pyrazoloacridine
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| Legacy Concept Name | Pyrazoloacridine
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| in_subset |
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| Preferred_Name | Pyrazoloacridine
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| Is_Value_For_GDC_Property | |
| Display_Name | Pyrazoloacridine
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| Maps_To | Pyrazoloacridine
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| PDQ_Open_Trial_Search_ID | 41418
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| Has_Target | |
| UMLS_CUI | C0280970
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| FDA_UNII_Code | L24XJN68OW
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| prefixIRI | NCIT:C1564
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| NCI_Drug_Dictionary_ID | 41418
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C1564
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called acridines.
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| NSC Number | 366140
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| PDQ_Closed_Trial_Search_ID | 41418
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 99009-20-8
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