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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C156399
http://purl.obolibrary.org/obo/NCIT_C156399
|
|---|---|
| Preferred Name | Emirodatamab |
| Definitions |
A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) FLT3 tyrosine kinase receptor (Fms-like tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, emirodatamab binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and FLT3 found on FLT3-expressing tumor cells. This activates and redirects CTLs to FLT3-expressing tumor cells, which results in the CTL-mediated cell death of FLT3-expressing tumor cells. FLT3, a cytokine receptor belonging to the class III tyrosine kinase receptors, is overexpressed or mutated in most B-lineage and acute myeloid leukemias (AMLs).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) FLT3 tyrosine kinase receptor (Fms-like tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, emirodatamab binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and FLT3 found on FLT3-expressing tumor cells. This activates and redirects CTLs to FLT3-expressing tumor cells, which results in the CTL-mediated cell death of FLT3-expressing tumor cells. FLT3, a cytokine receptor belonging to the class III tyrosine kinase receptors, is overexpressed or mutated in most B-lineage and acute myeloid leukemias (AMLs). |
|---|---|
| prefLabel | Emirodatamab
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| label | Emirodatamab
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| NCI_META_CUI | CL563094
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| PDQ_Closed_Trial_Search_ID | 795695
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| code | C156399
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| Has_Target | |
| prefixIRI | NCIT:C156399
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| in_subset |
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| Display_Name | Emirodatamab
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| Preferred_Name | Emirodatamab
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| FDA_UNII_Code | P9I9Z3MF7Z
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-FLT3/CD3 BiTE Antibody AMG 427
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| CAS_Registry | 2449199-61-3
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| NCI_Drug_Dictionary_ID | 795695
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 795695
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| Semantic_Type | Pharmacologic Substance
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