Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1561
http://purl.obolibrary.org/obo/NCIT_C1561
|
|---|---|
| Preferred Name | Monoclonal Antibody Lym-1 |
| Definitions |
A murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells. When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells. When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils. (NCI04) |
|---|---|
| prefLabel | Monoclonal Antibody Lym-1
|
| label | Monoclonal Antibody Lym-1
|
| PDQ_Closed_Trial_Search_ID | 41126
|
| code | C1561
|
| prefixIRI | NCIT:C1561
|
| in_subset | |
| Preferred_Name | Monoclonal Antibody Lym-1
|
| Maps_To | Monoclonal Antibody Lym-1
|
| NSC Number | 620858
|
| NCI_Drug_Dictionary_ID | 41126
|
| Legacy Concept Name | Monoclonal_Antibody_Lym-1
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41126
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
|
| UMLS_CUI | C0280726
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |