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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C156052
http://purl.obolibrary.org/obo/NCIT_C156052
|
|---|---|
| Preferred Name | BCMA x CD3 T-cell Engaging Antibody CC-93269 |
| Definitions |
A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-BCMA/CD3 T-cell engaging antibody CC-93269, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-BCMA/CD3 T-cell engaging antibody CC-93269, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival. |
|---|---|
| prefLabel | BCMA x CD3 T-cell Engaging Antibody CC-93269
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| label | BCMA x CD3 T-cell Engaging Antibody CC-93269
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| NCI_META_CUI | CL562897
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| PDQ_Closed_Trial_Search_ID | 795389
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| code | C156052
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| Has_Target | |
| prefixIRI | NCIT:C156052
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| in_subset |
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| Display_Name | BCMA x CD3 T-cell Engaging Antibody CC-93269
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| Preferred_Name | BCMA x CD3 T-cell Engaging Antibody CC-93269
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| Contributing_Source | CTRP
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| Maps_To | BCMA x CD3 T-cell Engaging Antibody CC-93269
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| NCI_Drug_Dictionary_ID | 795389
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 795389
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| Semantic_Type | Pharmacologic Substance
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