Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C156017
http://purl.obolibrary.org/obo/NCIT_C156017
|
|---|---|
| Preferred Name | Batiraxcept |
| Definitions |
A soluble fusion protein comprised of the extracellular domain of the receptor tyrosine kinase (RTK) AXL (UFO) fused to a human immunoglobulin G1 (IgG1) Fc domain, with potential antineoplastic activity. Upon administration, batiraxcept selectively binds to growth arrest-specific protein 6 (GAS6), the endogenous ligand for AXL. This may inhibit GAS6/AXL-mediated signaling, which plays a key role in tumor cell proliferation, survival, invasion and metastasis, as well as immune evasion and resistance to other anticancer agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of RTKs, is overexpressed by many tumor cell types and its expression is associated with drug resistance and poor prognosis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A soluble fusion protein comprised of the extracellular domain of the receptor tyrosine kinase (RTK) AXL (UFO) fused to a human immunoglobulin G1 (IgG1) Fc domain, with potential antineoplastic activity. Upon administration, batiraxcept selectively binds to growth arrest-specific protein 6 (GAS6), the endogenous ligand for AXL. This may inhibit GAS6/AXL-mediated signaling, which plays a key role in tumor cell proliferation, survival, invasion and metastasis, as well as immune evasion and resistance to other anticancer agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of RTKs, is overexpressed by many tumor cell types and its expression is associated with drug resistance and poor prognosis. |
|---|---|
| prefLabel | Batiraxcept
|
| label | Batiraxcept
|
| NCI_META_CUI | CL562760
|
| PDQ_Closed_Trial_Search_ID | 795349
|
| code | C156017
|
| Has_Target | |
| prefixIRI | NCIT:C156017
|
| in_subset |
See more
See less
|
| Display_Name | Batiraxcept
|
| Preferred_Name | Batiraxcept
|
| FDA_UNII_Code | B6840JH4EB
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To | Anti-AXL Fusion Protein AVB-S6-500
|
| CAS_Registry | 2268717-61-7
|
| NCI_Drug_Dictionary_ID | 795349
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 795349
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |