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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C156002
http://purl.obolibrary.org/obo/NCIT_C156002
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|---|---|
| Preferred Name | Soluble Interleukin-6 Receptor Subunit Alpha |
| Definitions |
Soluble interleukin-6 receptor subunit alpha is encoded by the human IL6R gene. This protein, which is produced by metalloproteinase-mediated cleavage of the membrane-bound form, is involved in the modulation of interleukin-6-mediated signaling by CD4-positive T-lymphocytes.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Soluble interleukin-6 receptor subunit alpha is encoded by the human IL6R gene. This protein, which is produced by metalloproteinase-mediated cleavage of the membrane-bound form, is involved in the modulation of interleukin-6-mediated signaling by CD4-positive T-lymphocytes. |
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| prefLabel | Soluble Interleukin-6 Receptor Subunit Alpha
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| label | Soluble Interleukin-6 Receptor Subunit Alpha
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| NCI_META_CUI | CL562744
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| code | C156002
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| prefixIRI | NCIT:C156002
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| OMIM_Number | 147880
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| in_subset | |
| Display_Name | Soluble Interleukin-6 Receptor Subunit Alpha
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| Preferred_Name | Soluble Interleukin-6 Receptor Subunit Alpha
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| Contributing_Source | CTRP
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| Swiss_Prot | P08887
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| DesignNote | Interleukin-6 (IL6) can bind membrane-bound and soluble forms of the interleukin-6 receptor subunit alpha (IL6R) with similar affinities. IL6-soluble IL6R complexes can interact with either membrane-bound or soluble forms of interleukin-6 receptor subunit beta (IL6ST; gp130). Binding of IL6-sIL6R to membrane-bound gp130 promotes IL6-mediated signaling pathways (IL-6 trans-signaling), while binding to soluble gp130 inhibits IL-6 trans-signaling.
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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