Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1560 http://purl.obolibrary.org/obo/NCIT_C1560
Preferred Name	Brequinar
Definitions	A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04)
prefLabel	Brequinar
label	Brequinar
Has_Salt_Form	http://purl.obolibrary.org/obo/NCIT_C1078
PDQ_Closed_Trial_Search_ID	40886
code	C1560
prefixIRI	NCIT:C1560
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Brequinar
FDA_UNII_Code	5XL19F49H6
Contributing_Source	FDA
Chemical_Formula	C23H15F2NO2
Maps_To	Brequinar
CAS_Registry	96187-53-0
NCI_Drug_Dictionary_ID	40886
Legacy Concept Name	Brequinar
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2169 http://purl.obolibrary.org/obo/NCIT_C1557
PDQ_Open_Trial_Search_ID	40886
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0280509

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