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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C155945
http://purl.obolibrary.org/obo/NCIT_C155945
|
|---|---|
| Preferred Name | NLRP3 Agonist BMS-986299 |
| Definitions |
A nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT, LRR and PYD Containing Protein 3; NALP3) agonist with potential immunomodulatory and antineoplastic activities. Upon administration, NLRP3 agonist BMS-986299 binds to and activates NLRP3, potentially promoting NLRP3 inflammasome-mediated secretion of interleukin-8 (IL-8), which may induce tumoricidal activity of natural killer (NK) cells against tumor cells. NLRP3, a sensor component of the NLRP3 inflammasome plays a significant role in immunity and inflammation, and may protect against tumorigenesis in some cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT, LRR and PYD Containing Protein 3; NALP3) agonist with potential immunomodulatory and antineoplastic activities. Upon administration, NLRP3 agonist BMS-986299 binds to and activates NLRP3, potentially promoting NLRP3 inflammasome-mediated secretion of interleukin-8 (IL-8), which may induce tumoricidal activity of natural killer (NK) cells against tumor cells. NLRP3, a sensor component of the NLRP3 inflammasome plays a significant role in immunity and inflammation, and may protect against tumorigenesis in some cancers. |
|---|---|
| label | NLRP3 Agonist BMS-986299
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| prefLabel | NLRP3 Agonist BMS-986299
|
| in_subset |
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| Preferred_Name | NLRP3 Agonist BMS-986299
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| Is_Value_For_GDC_Property | |
| Display_Name | NLRP3 Agonist BMS-986299
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| Maps_To | NLRP3 Agonist BMS-986299
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| PDQ_Open_Trial_Search_ID | 795266
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| FDA_UNII_Code | VS58MO4P47
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| prefixIRI | NCIT:C155945
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| NCI_Drug_Dictionary_ID | 795266
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C155945
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| type | |
| PDQ_Closed_Trial_Search_ID | 795266
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 2242952-69-6
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| NCI_META_CUI | CL562818
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