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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C155775
http://purl.obolibrary.org/obo/NCIT_C155775
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|---|---|
| Preferred Name | Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11 |
| Definitions |
Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers. |
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| prefLabel | Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11
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| label | Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11
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| NCI_META_CUI | CL556250
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| PDQ_Closed_Trial_Search_ID | 794988
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| code | C155775
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| Has_Target | |
| prefixIRI | NCIT:C155775
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| in_subset |
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| Display_Name | Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11
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| Preferred_Name | Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11
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| FDA_UNII_Code | ER09HM7LIR
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11
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| NCI_Drug_Dictionary_ID | 794988
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 794988
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| Semantic_Type | Pharmacologic Substance
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