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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1546
http://purl.obolibrary.org/obo/NCIT_C1546
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|---|---|
| Preferred Name | Cryptophycin |
| Definitions |
The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI) |
|---|---|
| prefLabel | Cryptophycin
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| label | Cryptophycin
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| code | C1546
|
| prefixIRI | NCIT:C1546
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| in_subset | |
| Preferred_Name | Cryptophycin
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| FDA_UNII_Code | XO974V2M5T
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| Contributing_Source | FDA
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| Maps_To | Cryptophycin
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| CAS_Registry | 124689-65-2
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| NSC Number | 667642
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| Legacy Concept Name | Cryptophycin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Antibiotic
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| UMLS_CUI | C0257217
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