Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1544
http://purl.obolibrary.org/obo/NCIT_C1544
Preferred Name

Romidepsin
Definitions
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins.
prefLabel
Romidepsin
label
Romidepsin
CHEBI_ID
CHEBI:61080
PDQ_Closed_Trial_Search_ID
42600
code
C1544
Has_Target
prefixIRI
NCIT:C1544
in_subset
Display_Name
Romidepsin
Preferred_Name
Romidepsin
FDA_UNII_Code
CX3T89XQBK
Contributing_Source
CTRP
FDA
Chemical_Formula
C24H36N4O6S2
Maps_To
Romidepsin
CAS_Registry
128517-07-7
NSC Number
630176
NCI_Drug_Dictionary_ID
42600
Legacy Concept Name
Depsipeptide
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. Romidepsin is a type of depsipeptide and histone deacetylase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42600
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
UMLS_CUI
C1527027
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