Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1542 http://purl.obolibrary.org/obo/NCIT_C1542
Preferred Name	Pibrozelesin
Definitions	A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
Type	http://www.w3.org/2002/07/owl#Class

definition	A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
prefLabel	Pibrozelesin
label	Pibrozelesin
PDQ_Closed_Trial_Search_ID	42429
code	C1542
prefixIRI	NCIT:C1542
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Pibrozelesin
FDA_UNII_Code	IHK933KCIC
Contributing_Source	FDA
Chemical_Formula	C32H36BrN5O8
Maps_To	Pibrozelesin
CAS_Registry	154889-68-6
NCI_Drug_Dictionary_ID	42429
Legacy Concept Name	KW_2189
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A semisynthetic anticancer drug that is a type of antitumor antibiotic.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2156
PDQ_Open_Trial_Search_ID	42429
Semantic_Type	Organic Chemical Pharmacologic Substance Antibiotic
UMLS_CUI	C0254093

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