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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C153354
http://purl.obolibrary.org/obo/NCIT_C153354
|
|---|---|
| Preferred Name | SLC6A8 Inhibitor RGX-202 |
| Definitions |
An orally available, small molecule inhibitor of the creatine transporter, solute carrier family 6, member 8 (SLC6a8), with potential antineoplastic activity. Upon oral administration, RGX-202 inhibits phosphocreatine uptake by SLC6a8, thereby reducing intracellular levels of phosphocreatine available for ATP synthesis in tumor cells. SLC6a8 is overexpressed in some cancer types and inhibition of its activity may potentially limit tumor cell growth and metastasis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available, small molecule inhibitor of the creatine transporter, solute carrier family 6, member 8 (SLC6a8), with potential antineoplastic activity. Upon oral administration, RGX-202 inhibits phosphocreatine uptake by SLC6a8, thereby reducing intracellular levels of phosphocreatine available for ATP synthesis in tumor cells. SLC6a8 is overexpressed in some cancer types and inhibition of its activity may potentially limit tumor cell growth and metastasis. |
|---|---|
| prefLabel | SLC6A8 Inhibitor RGX-202
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| label | SLC6A8 Inhibitor RGX-202
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| NCI_META_CUI | CL554455
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| PDQ_Closed_Trial_Search_ID | 794147
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| code | C153354
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| Has_Target | |
| prefixIRI | NCIT:C153354
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| in_subset |
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| Display_Name | SLC6A8 Inhibitor RGX-202
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| Preferred_Name | SLC6A8 Inhibitor RGX-202
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| Contributing_Source | CTRP
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| Maps_To | SLC6A8 Inhibitor RGX-202
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| NCI_Drug_Dictionary_ID | 794147
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 794147
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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