Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1533
http://purl.obolibrary.org/obo/NCIT_C1533
|
|---|---|
| Preferred Name | Pemetrexed Disodium |
| Definitions |
The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. |
|---|---|
| prefLabel | Pemetrexed Disodium
|
| label | Pemetrexed Disodium
|
| CHEBI_ID | CHEBI:63722
|
| PDQ_Closed_Trial_Search_ID | 42328
|
| code | C1533
|
| Has_Target | |
| prefixIRI | NCIT:C1533
|
| in_subset |
See more
See less
|
| Display_Name | Pemetrexed Disodium
|
| Preferred_Name | Pemetrexed Disodium
|
| FDA_UNII_Code | 2PKU919BA9
|
| Contributing_Source |
CTRP
FDA
|
| Chemical_Formula | C20H19N5O6.2Na
|
| Maps_To | Pemetrexed Disodium
|
| CAS_Registry | 150399-23-8
|
| NSC Number | 698037
|
| NCI_Drug_Dictionary_ID | 42328
|
| Legacy Concept Name | Pemetrexed
|
| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used alone or with another drug to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment of other types of cancer. Pemetrexed disodium blocks DNA synthesis and may kill cancer cells. It is a type of folate antagonist.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42328
|
| Accepted_Therapeutic_Use_For | Malignant pleural mesothelioma; Non-small cell lung cancer
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0936142
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |