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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C153261
http://purl.obolibrary.org/obo/NCIT_C153261
|
|---|---|
| Preferred Name | Anti-Globo H Monoclonal Antibody OBI-888 |
| Definitions |
A monoclonal antibody targeting the hexasaccharide glycosphingolipid antigen Globo H with potential immunostimulating, anti-angiogenic and antineoplastic activities. Upon infusion, anti-Globo H monoclonal antibody OBI-888 may induce tumor cell destruction via the activation of antibody dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC), and may reduce immunosuppression. Globo H is a tumor-associated antigen (TAA) expressed on the surface of various types of cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A monoclonal antibody targeting the hexasaccharide glycosphingolipid antigen Globo H with potential immunostimulating, anti-angiogenic and antineoplastic activities. Upon infusion, anti-Globo H monoclonal antibody OBI-888 may induce tumor cell destruction via the activation of antibody dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC), and may reduce immunosuppression. Globo H is a tumor-associated antigen (TAA) expressed on the surface of various types of cancer cells. |
|---|---|
| prefLabel | Anti-Globo H Monoclonal Antibody OBI-888
|
| label | Anti-Globo H Monoclonal Antibody OBI-888
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| NCI_META_CUI | CL554489
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| PDQ_Closed_Trial_Search_ID | 794060
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| code | C153261
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| Has_Target | |
| prefixIRI | NCIT:C153261
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| in_subset |
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| Display_Name | Anti-Globo H Monoclonal Antibody OBI-888
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| Preferred_Name | Anti-Globo H Monoclonal Antibody OBI-888
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| FDA_UNII_Code | JI5TBH62QP
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-Globo H Monoclonal Antibody OBI-888
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| CAS_Registry | 2227156-40-1
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| NCI_Drug_Dictionary_ID | 794060
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 794060
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| Semantic_Type | Pharmacologic Substance
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