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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C153159
http://purl.obolibrary.org/obo/NCIT_C153159
|
|---|---|
| Preferred Name | Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591 |
| Definitions |
A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration, actinium Ac-225 anti-PSMA monoclonal antibody J591 binds to the extracellular domain of PSMA with high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA, a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed in tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration, actinium Ac-225 anti-PSMA monoclonal antibody J591 binds to the extracellular domain of PSMA with high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA, a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed in tumor cells. |
|---|---|
| prefLabel | Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591
|
| label | Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591
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| NCI_META_CUI | CL554298
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| PDQ_Closed_Trial_Search_ID | 793676
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| code | C153159
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| Has_Target | |
| prefixIRI | NCIT:C153159
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| in_subset | |
| Preferred_Name | Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591
|
| Maps_To | Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591
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| NCI_Drug_Dictionary_ID | 793676
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 793676
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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