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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C153129
http://purl.obolibrary.org/obo/NCIT_C153129
|
|---|---|
| Preferred Name | Ubamatamab |
| Definitions |
A bispecific, human monoclonal antibody with potential antineoplastic activity. REGN4018 contains two antigen-recognition sites: one for human CD3, a T cell surface antigen that is part of the T cell receptor complex, and one for human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), a member of the mucin family of glycoproteins that is overexpressed by several epithelial cancers, including ovarian cancer. Upon administration, ubamatamab binds to both T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific, human monoclonal antibody with potential antineoplastic activity. REGN4018 contains two antigen-recognition sites: one for human CD3, a T cell surface antigen that is part of the T cell receptor complex, and one for human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), a member of the mucin family of glycoproteins that is overexpressed by several epithelial cancers, including ovarian cancer. Upon administration, ubamatamab binds to both T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells. |
|---|---|
| prefLabel | Ubamatamab
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| label | Ubamatamab
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| NCI_META_CUI | CL554386
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| PDQ_Closed_Trial_Search_ID | 793937
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| code | C153129
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| Has_Target | |
| prefixIRI | NCIT:C153129
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| in_subset |
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| Display_Name | Ubamatamab
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| Preferred_Name | Ubamatamab
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| FDA_UNII_Code | 6BUL1G4D60
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Anti-MUC16/CD3 BiTE Antibody REGN4018
Anti-MUC16/CD3 Bispecific Antibody REGN4018
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| CAS_Registry | 2305629-50-7
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| NCI_Drug_Dictionary_ID | 793937
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 793937
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| Delete | Subject | Author | Type | Created |
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